New gene regulatory mechanism in monocytes | Department of Medical Chemistry

In collaboration with Agnieszka Robaszkiewicz’s group (Lodz, Poland), Laszlo Virag and Zsolt Regdon published a paper in BBA Gene Regulatory Mechanisms about gene expression regulation in monocytes. In this study they have investigated how the tumor suppressor protein Rbl2 regulates gene expression. They identified a nuclear protein PARP1 as a mediator of Rbl2’s gene regulatory effects. The genes regulated by these two proteins could be assigned to 8 groups based on their responsiveness to Rbl2 and PARP1. The work also identified chromatin modifier enzymes mediating the gene regulatory functions of these two proteins.